Tumors: not just a backup: the double specificity of UBA6
The ubiquitylation of target proteins is one of the most important post-translational modifications and plays essential roles in numerous cellular processes. Ubiquithylation is performed by a sequential enzyme cascade of E1 activating enzymes, E2 conjugating enzymes and E3 binding enzymes. For many years it was thought that UBA1 was the only E1 enzyme that activates …
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